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World Wide Web benefits people by disseminating information limitless for various reasons. Web-based business applications as platform used greatly for communication between people and businesses. Thus, web developers facing some challenges throughout web-based business applications development include its processes to conform business excel. This paper examine the results of a research exercise involving comprehensive literature studies and other relevant information analysis, which aims to discover the key challenges during the development of web-based business applications. Such key challenges may consider important for web developers to building better web-based business applications.