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From the point of view of cost-reduction and benefit-improvement, this paper puts up with a new ECommerce mode for the medical industry—E-Commerce based on supply chain management (SCM). At the same time, this paper qualitatively analyzes the risks of the mode, including risk of management, risk of technology, risk of human resource and risk of the mode itself. At last, the paper puts forward a set of risk management models for this ECommerce mode according to the basic principles pf project management.