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From 1999, China started to the project of “Development of Western Region of China” and many preferential policies were issued by the central government. However, after almost 5 years, compared with eastern region, the development of infrastructure is still relatively lower. As to the development of E-commerce, the most typical phenomenon is unbalance which means that the eastern region is much faster than the western because of territorial and economic factors. So it is necessary to get a whole picture and get a clear understanding of problems of current situation of E-commerce in west part of China in order to accelerate it. In this article, the difficult points of E-commerce development in west region are discussed, such as the law issue, infrastructure, information service providers and talents people and some strategies will be given finally based on the current situation of E-commerce in west part of China.