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With the fast development of the global economy, how to deliver the right products to the end-users in the demanding time and places becomes more and more important to the enterprises. In order to improve the competitive advantages, Chinese enterprises, especially the large manufacturers, need to develop e-logistics function and modern supply chain management systems. This paper describes the changing environment, such as competition, global trends, and logistics operations. Then the e-logistics is discussed, and it presents that the Descartes can improve the level of the information sharing and creates a new source of advantage to ensure competitiveness in today’s dynamic manufacturing marketplace. At last some suggestions are given, including establishing an integrated network, selecting the right industries, and so on.