The potential and use of Information and Communication Technologies (ICT) to cater for digital health depend on the context and its meaning-making. Therefore, the concepts and materialization of digital health in Africa are specific for Africa. This transdisciplinary and reflexive paper introduces and positions African particulars pertaining ICTs and an emerging narrative of digital health in Africa. The narrative pivots decentering and the necessary interplay of African community engagement, workforce enhancement, and thought leadership as the means towards inclusive and embedded digital health interventions in Africa.