Human-computer interaction for development (HCI4D) is an interdisciplinary field aimed at understanding and designing technologies for under-served, under-resourced, and under-represented populations around the world. The interdisciplinary nature complicates knowledge transfer and articulation between the disciplines contributing to the HCI4D domain with the consequence that researchers in one sub-domain do not always build on the extant theoretical and methodological progress in other sub-domains. The purpose of this paper is to propose a framework for HCI4D that could facilitate a better understanding of this domain, for knowledge mobilisation and articulation between researchers in HCI4D and the related field of information and communication technology for development (ICT4D). Previous studies have presented an overview of the HCI4D field in terms of the geographies it covers, technologies it targets, and its varied epistemological and methodological underpinnings. This paper builds on those methodologies and findings to conduct a systematic literature review which revisits the domain questions, thus, the core issues and topics (why), the phenomenon of interest (what) and the research methods (how). A comparison of the findings from three seminal HCI4D papers led to the identification of three core issues (motor themes) namely, context, design and development. Based on Ward’s idea of a knowledge mobilisation framework, the findings from the systematic literature review are then synthesised and presented as a framework which comprises the core issues, recurring themes and the salient elements for each of the domain questions. The contribution is a knowledge mobilisation framework to enrich discussions on positioning HCI4D as research field.