In recent years, there has been increased use of electronic healthcare (e-health) in developing countries. E-health can contribute immensely to addressing the myriad of health challenges facing these countries (e.g., extending geographic access to care, improving management of health information). The emergence of e-health, however, has raised individuals’ concerns about personal health information (PHI) privacy, being often identified as a key barrier to the successful implementation of e-health. To ensure the sustained growth and development of e-health in developing countries it is important to understand and respond appropriately to individuals’ concerns regarding the electronic storage, use and communication of PHI as well as the factors driving these concerns. This paper reports on a study which seeks to address the above research problem by developing and examining a model of key determinants of individual PHI privacy concerns in developing countries. More specifically, the study examines a model of the impacts of individual characteristics such as gender, individual experiences such as computer experience, and individual beliefs such as trust in e-health systems and trust in health services providers, on PHI privacy concerns. A survey study which tests the proposed model in the healthcare setting of Ghana, a Sub-Saharan African nation, is outlined. Implications for research and practice are also discussed.