The nursing discipline is increasingly confronted with far-reaching challenges that are a prominent subject in public discourse. Factors such as growing numbers of chronically ill patients and an ongoing decrease in medical personnel impose unprecedented strain on clinical care providers and nurses, which requires high levels of resilience on an individual and organizational level. The introduction of digital information and communication technology (ICT) in the workplace is intended to counteract these challenges and foster resilient everyday care. However, studies that investigate the interplay of digitalization and individual resilience are scarce. Hence, we propose a mixed-method approach to explore how ICT use in a clinical work setting influences nurses’ sense of coherence. This construct has been used as a theoretical foundation to investigate resilience in nursing. Further, the exploration of individual coping strategies in the light of ICT-related disturbances in the workplace and associated job-related outcomes complement the research agenda.