Conceptual models are used to visualise, envisage, and communicate the requirements, structure, and behaviour of a system. Particularly, during design and analysis phases, a model can serve as a tool to recognise different components, elements, actors, and relationships involved in a system. However, as a domain becomes complex, multiple models are needed to capture different aspects of a system. Further, each conceptual model develops using different grammars, methods, and tools. Therefore, using multiple models to represent a complex system may result in several problems, and challenges. This research aims to identify, analyse, and classify the different problems and issues encountered when using multiple models during information systems analysis and design through a structured literature review. Several problems are identified and are classified into seven main categories based on their common characteristics. The results of this study may serve as a baseline information for researchers in further understand-ing different modelling approaches and how multiple models can be used in harmony and reduce risks and issues. Also, the list of problems gathered will give insights to professionals on which issues they may possibly encounter when inter-relating various models.