One of the objectives of E-government is to foster citizen participation in government-related activities and services. For this to happen, accessibility of these E-government services is crucial for all citizens, more specifically for persons with disabilities (PWD). While several studies have evaluated the accessibility of E-government services to PWD, most fall short on providing empirical and context-specific experiences from the perspective of PWD. The purpose of the study is to examine the experiences of the visually impaired in accessing E-government services in Ghana so as to inform political leadership and societal decisions towards improving inclusivity and accessibility of E-government services for PWD. Based on the interviews carried out with 18 visually impaired, seven overarching themes were identified, categorised into the three dimensions of socio-political, technological and contextual respectively. Given that few studies have examined accessibility from the perspective of PWD in developing countries and particularly in Africa, these findings offer unique insight of the amalgamated factors that lead to the exclusion of PWD from E-government services in these contexts.