Information technology (IT) is an important enabler of innovative learning scenarios. Today, numer-ous IT-enabled learning scenarios – often referred to as technology-mediated learning (TML) – such as massive open online courses, are applied worldwide across different cultures. However, little in-sights are available regarding the appropriation of TML and how culture influences the appropriation process. Based on adaptive structuration theory and espoused cultural values, we develop and evalu-ate a theoretical model capturing the cultural effects in the context of TML appropriation. By means of structural equation modeling and a partial least squares approach, we research the moderating role of espoused cultural values and its influence on TML appropriation. The results show that faithfulness, comfort with technology, and collaborative learning appropriation significantly affect learning suc-cess as appropriation outcome. Moreover, the results indicate that espoused cultural values influence the appropriation of TML. The present paper thus theoretically contributes to the scientific discussion concerning TML appropriation and the impact of culture on the deployment of IT while also making a practical contribution by deriving implications for TML application across different cultures.