Clinical practice guidelines are knowledge uptake instrument that support decision making by the physicians. They are often implemented as computer-interpreted guidelines that are embedded in a hospital information system. We argue that computer-interpreted guidelines should be considered as regular information system, thus their development should follow all the steps of system analysis and design, starting with exploration and definition of user requirements. In this paper we propose the ActCPG conceptual framework to establish basic user requirements for implementing computer-interpreted guidelines. This framework relies on the Activity Theory to structure and decompose information coming from a clinical practice guideline and associated narrative so UML use cases can be developed. We illustrate operation of the ActCPG framework with an example of a practice guideline for a management of clinically obese children enrolled in some obesity program.