This paper argues that the development of a critical approach to technology from an ANT perspective is both possible and necessary. This approach to critique is not based on the belief in the autonomous and rational human agent since it fully acknowledges human/technological entanglement. It is argued that such an approach could make a contribution to the field of critical research of information systems (CRIS). It is also argued that an emphasis on critique is needed within the corpus of ANT studies which are often accused of managerialism. It is further argued that a form of critique is possible within ANT in spite of various sceptical views. In the light of the processes of translation in the formation of network, a conception of critique is developed on the basis of Latour’s view of “irreduction” of entities. The central critical question deals with the ways in which entities are betrayed within the process of translation.