Most governments around the world are fast advancing in the provision of services to their citizens through the web. However, developing countries still lag behind in the adoption and use of ICTs in government for inclusive purposes, specifically for persons with disabilities (PWDs) who tend to be side-lined from the population mainstream. Studies focusing on E-government accessibility for PWDs have been minimal from the developing countries context; and this is despite the fact that over eighty percent of the over one billion populations living with disabilities worldwide reside in the developing countries. For E-government to achieve its purpose of providing fast and efficient services to citizens, there is the need to adopt a context-oriented approach. Against this background, this paper proposes a conceptual framework for improving E-government accessibility for PWDs in the developing countries context. Through a systematic synthesis of the literature on E-government accessibility especially in developing countries, a conceptual framework, termed the E-government Accessibility Development Model (EADM) is proposed. EADM describes accessibility challenges of PWDs by identifying contextual barriers of E-government accessibility from multiple stakeholder perspective in developing countries.