The combination of information obtained from data mining technique from physicochemical and organoleptic data analysis allowed similarities between the wines of the nine sub-regions in the Demarcated Region of Vinho Verde. Through clustering techniques, four clusters were identified, each characterized by its centroid. The measure of information gain, together with supervised rule-based learning, was used to find the differentiating characteristics. This study allowed the interconnection of the characteristics of the wines of these sub-regions, which can improve the decision making on the profiles of these same wines.