On the one hand, predictive analytics is an important field of research in Information Systems (IS); however, research on predictive analytics in healthcare is still scarce in IS literature. One area where predictive analytics can be of great benefit is with regard to unplanned readmissions. While a number of studies on readmission prediction already exists in related research areas, there are few guidelines to date on how to conduct such analytics projects. To address this gap the paper presents the general process to develop empirical models by Shmueli and Koppius (2011) and extends this to the specific requirements of readmission risk prediction. Based on a systematic literature review, the resulting process defines important aspects of readmission prediction. It also structures relevant questions and tasks that need to be taken care of in this context. This extension of the guidelines by Shmueli and Koppius (2011) provides a best practice as well as a template that can be used in future studies on readmission risk prediction, thus allowing for more comparable results across various research fields.