Cancer, a chronic disease has become one of the primary causes of death in advanced countries. The diagnosis, medication and treatment for cancer is very expensive. Healthcare providers, especially in cancer care, need to automate and accelerate access to patient data and evidence based decision making along with greater quality control and safety. Oncology information systems (OIS) provide a simple solution for this. This study compared 3 different leading international oncology information systems capable of delivering high-value, patient centred care to cancer patients in the Australian context. This work analysed functionality, usability and interoperability of these systems for the Australian healthcare environment and their integration with existing systems and assets. Critical success factors in the design of platforms to make them perform better from clinicians’ and patients’ points of view have also been discussed.