The growing importance of Enterprise 2.0 is not adequately reflected in research on its implementation. This study contributes to understanding the change factors specific to Enterprise 2.0 initiatives. It draws upon grounded theory to compare sixteen case studies, integrates the findings in the context of socio-technical change and discusses similarities and differences compared to the field of ERP. The resulting change factors specific to Enterprise 2.0 initiatives can support practitioners in avoiding pitfalls of change management and present a starting point for researchers to empirically investigate change in Enterprise 2.0 initiatives.