Although information is a concept that represents the ability of human’s meta-cognition to create, accept and understand, this is insignificant when little is known how information exists and how it is manipulated with different strategies. This research presents the impact of information and meta-cognition to Information Literacy (IL) strategy, which should consider them thoroughly. Furthermore, it investigates two worlds of existing information: the physical and the virtual world, and it uses systems science perspective with a qualitative observation. This research is done on theoretical basis and it includes a critique regarding the way we conceive information. The result is instigative. It raises the consciousness how we humans’ are dependent on our meta-cognition and how this indicates the way we consider information using IL strategy.