Recent developments in neurosciences are being used in several fields such as economics, marketing and other social related sciences. Neurosciences are being used in different realms, from theoretical to philosophical, and it is creating new approaches to established fields. We believe that all social sciences should look at how the neurosciences could contribute to their field. We view Information Systems as a conjunction of a Technical System and a Social System, and therefore we think that there is the need to analyze whether the neurosciences can contribute to the field. We propose two different approaches of how neurosciences could contribute to the IS field. The first one analyzes parallelisms between Neuroeconomy and Information Systems, and the second one applies the Neurophilosophical Methodology in an attempt to ground Pragmatism’s premises.