Over past several decades, the management information systems (MIS) community has adopted theories, methodologies, philosophical bases, and assumptions from sister disciplines. This paper reports the changing nature of information science (IS) towards multi-disciplinarity and its development over the past decade. It also examines the contribution of informetrics to MIS research in delineating the intellectual structure of information systems, comparing cumulative research traditions, demonstrating theoretical differences between competing approaches, tracing a paradigm shift. Development in IS provides MIS researchers with ample opportunities for cross-disciplinary research, new research tools, new theories to understand information systems phenomena, etc.