This research proposes and empirically tests a model of post adoption process improvements realized through use of partners’ Internet-based e-business applications. We identify constructs proposed within adoption and post-adoption use theoretical models as well as presented in existing inter-organizational systems research. Our analysis reveals purely organization-based factors; namely, information systems/technology infrastructure and propensity for like innovations; shape perceptions of process improvement, while technology, or innovation, based and external factors, i.e., ease of use and facilitating conditions respectively, serve as moderators of the relationships between predictors and process improvement.