This article presents the work of a research and action group that promoted the creation of spin-outs by women researchers in science and engineering. The project involves developing and offering a community of practice to support women university researchers who have the potential to create spin-outs; the community’s goal is to develop and maintain networking opportunities and reciprocal relationships, and facilitate the multidirectional flow of academic knowledge and expertise between researchers and their students. From an academic point of view, this paper aims at answering the research question of whether a community of practice mediated by IT tools can provide a useful support and generate a positive impact on the launching of a startup by women in STEM. Finally, to measure the success of the community, two surrogates will be used: satisfaction and effectiveness (in assisting decision)