As the world experienced an acceleration in digital workplace transformation, organisations and employees have adapted new practices that meet the challenges of hybrid work. Work technologies have also experienced a parallel evolution to support the unique dynamics of the modern hybrid work that is largely digital. This association between the human and technology are believed to contribute to the reconfiguration of digital work practices. Our study adopts a qualitative approach with a single case study to investigate the factors that influence the reconfiguration of digital work practices in hybrid work. Based on a multi-national IT organisation, study findings indicate that human agency, digital work technologies, cultural practices, and challenges of hybrid work have contributed to the reconfiguration of digital work practices. These findings advance our understanding of the reciprocal relationship between the digital and human but also in informing practices that support employee engagement and leadership of a hybrid workforce.