IT-enabled sustainable innovation (SI) has been harnessed by organizations to strategically address sustainability concerns. To facilitate the development of IT-enabled SI, organizations need to orchestrate their sustainability and technology resources. This orchestration is influenced by the complementarity between organizational sustainability orientation (SO) and technology orientation (TO), which remains underexplored in the current literature. Guided by resource orchestration theory, this study explores how SO and TO complement each other in the development of IT-enabled SI through case studies with four organizations. Based on initial research findings, an IT-enabled SI development matrix is proposed that demonstrates how organizations can realize the complementarity of SO and TO in IT-enabled SI development. This study extends current research by revealing the link between SO-TO complementarity and IT-enabled SI development. Practically, the proposed matrix is a useful tool that facilitates organizations’ understanding of IT-enabled SI development and the importance of corresponding strategic orientation and resource management.