This paper presents the theoretical background to explore the relationship and identify factors involved in the connection of art with science information systems through artistic experience to enhance innovation competencies of science, particularly STEM, students in higher education. This theory informs the design of an art-science fusion workshop (ASF-WS) to foster innovation. The workshop intends to create an interspatial interactive learning environment by connecting the remote information systems of elite interdisciplinary performing arts (classical singing, piano, and dance), literature (poetry), embodied perception, somatic learning, and STEM-related academic fields in higher education (HE). The ASF-WS design is taking in consideration the latest views of neuroscience on embodiment, human cognitive functions and it is structured in accordance with the soft skills of innovation competency. It intends to provide a pedagogical measure that allows data collection of innovation skill changes in students.