Non-profit cancer organisations aim to reduce the illness caused by cancer by providing emotional support and practical information using different online resources. Cancer podcasts are one type of resource provided by those organisations to support cancer-affected people by transmitting information via audio in the form of interviews, conversations, and panel discussions. However, little is known about the quality features of these podcasts from the perspective of users. This is important to provide insights into designing podcasts that can meet the needs of cancer-affected people. Integrating the IQ assessment framework, source credibility theory, and two-factor theory of website design, this study collected data via semi-structured interviews with 14 participants to develop a framework to assess the quality of cancer-related podcasts. Results showed that all features underlying the credibility, content, and design constructs were fundamental, except for the visual appearance of the website which constituted a motivating factor for using podcasts.