This research proposes the use of value stream mapping to guide the choice of Healthcare 4.0 (H4.0) digital applications that are more prone to support the enhancement of value flows in health services. A three-step approach is developed, beginning with mapping the current and future state of the value streams, identifying improvement kaizen bursts, and finally evaluating H4.0 digital applications that best underpin improvements and comply with attributes that characterize well-succeeded technological innovations. This method is illustrated through a case study in the sterilization unit of a large university hospital. With the advent of Industry 4.0, the accelerated pace at which digital transformation has been conducted challenges healthcare organisations to prioritise the digital applications with the largest positive impact in their operations assertively. Our propositions provide means to integrate H4.0 into healthcare towards more effective health services values streams.