Cyber-physical systems promise a complete networking of all actors and resources involved in production and thus an improved availability of information. In this context decision support systems enable appropriate processing and presentation of the captured data. In particular, production scheduling could benefit from this, since it is responsible for the short-term planning and control of released orders. Since decision support systems and cyber-physical systems together are not yet widely used in production scheduling, the aim of this research study is to analyze the adoption of these technologies. In order to do so, we conducted a qualitative interview study with experts on production scheduling. Thereby, we identified eleven influencing factors and 22 related challenges, which affect the adoption of decision support systems in production scheduling in the context of cyber-physical systems. The results help to explain the adoption and can serve as a starting point for the development of those systems.