Despite the vital role that mobile applications will play in the implementation of healthcare plans in the Saudi Vision 2030, several factors may influence the process. Due to the conflict of interest, lack of exposure, resistance to change, as well as limited technical knowledge of the apps, the Saudi Arabian society may inadvertently impede the government’s objectives. All the challenges could be related to individual perceptions, technical complexities, social influence, as well as organizational reliability and preparedness. The earlier the authorities identify the issues and respond to them, the faster it will be to succeed in the implementation of mobile health (m-health) and subsequent attainment of the Vision 2030 health goals. This study conducted a review of literature in this context. The proposed model and factors identified will be tested to understand patients’ perceptions of m-health applications. The results will be beneficial to increase the adoption rates of m-health in Saudi Arabia.