Healthcare service systems require care follow-up procedures using clinical practice guidelines targeting specific patient groups. Studies have introduced various methods for providing patient care, but system design for follow-up support remains limited to a few specific types of disease management. A general need is identified in a climate of increased demand on fewer doctors, for which mobile systems can provide solutions. In this paper, we present a post-treatment follow-up Decision Support framework for use by patients and physicians. The proposed care support is cloud-based and offers online and asynchronous Patient-Physician interaction, with a ratings system designed to ensure continuing improvement in outcomes. Using a design science research process the solution framework has been prototyped and evaluated with representative physicians and users. Our framework provides a model for extending care service systems to inform better follow-up decision-making.