Digital currencies (DC) continue to gain public and research attention as an alternative paradigm of currency, its value and exchange. Because of the growing DC research in the Information Systems (IS) domain, it is necessary to distinguish between existing DC research coverage and areas for future exploration. This article offers an up to date review of IS research on digital currencies in terms of the locus and focus of issues , theories, methods, and findings in order to provide direction for future research. The study uses a systematic literature review method to examine IS articles published between 2010 and 2016. The review identified eighteen articles in highly ranked IS journals and conferences. Based on results from our investigation, we chart out end-user, organisation, and systems related future research directions.