Healthcare is a large, complex industry, involving many stakeholders, involving issues at individual, organizational, inter-organizational, and/or international levels. The ELeRS framework was recently formulated to help scope e-learning research in the healthcare industry. In this paper, we describe some practical guidelines to assist researchers use this framework. These guidelines assist researchers to either formulate an independent research study or a series of related studies, using the defined framework. A summary of the framework is first presented, followed by the guidelines, and then a concrete example of how it can be applied. Our experience shows ELeRS systematize the scoping of new research in e-learning. Some lessons learnt are discussed also.