This paper discusses the alignment of the enterprise with its Information Systems (IS) from the perspective of policy determinations, past research studies and implications for the future. Policy determinations from the US, UK and Australia are discussed, while past and current alignment research studies are reviewed and contrasted. It is conjectured that where Enterprise Architecture (EA) treatment is not mandated, there may still be a positive role for architecture in the alignment of the enterprise and its IS. Some well known EA frameworks and methods are reviewed and compared as viable alignment vehicles. The paper concludes with implications for future alignment research studies and policy decisions, and outlines a current research program that is investigating the use of enterprise architecture in government agencies for the alignment of business strategy and IS.