The paper’s main purpose is to show the importance, and some improvements of mobile telemedicine information systems in patients’ compliance. First the basic definitions of cloud-oriented architecture are provided, and based on that the prerequisites for cloud-ready applications development. This is the basis on which our solution is build. Described is a solution, developed to be in service of patients with different diseases, and their physicians. The web application gives physicians the ability of developing template of care plan for some diagnoses and then to personalize it for specific patients and their needs. The mobile application is disease management tool and it is developed to be in help of patients. Its purpose is to notify them for the next steps of the care plan, which of course are prescribed, and will be followed up by their physicians.