Information Systems for decision support are used in healthcare for many years. While administrative, accounting-related systems have been accepted with more or less success by decision-makers, this study is devoted to methods of conceptual modeling in clinical information management ? especially against the background of assuring a high quality level in an increasingly networked healthcare sector. There are large differences in the use of models of Clinical Practice Guidelines (CPG) and their implementation in process descriptions as Clinical Pathways (CP). The paper examines the usefulness of diagrammatic representations and models as well as methodological support in general as well as the willingness of individuals to deal with these. Based on an exploratory case study, the concept of a model-driven method from the perspective of domain experts is evaluated and the impacts for modeling approaches are derived.