The field of human-computer interaction (HCI) is a significant subset of information systems. Despite its importance, there are few systematic reviews of HCI literature, especially as it pertains to the IS discipline. This study attempts to contribute to the discipline by reporting on a review of HCI research published in seven top IS journals over six years (2003–2009). Our review suggests a few critical gaps: 1) there is a dearth of research focusing on CMC-related issues, especially with respect to dyadic communication, 2) while past research acknowledges that culture plays an important role in HCI, and has implications for interface design, few studies have focused on cultural issues, 3) more research is needed in the human-computer interaction involving enterprise systems, and 4) more focus needs to be paid to the “levels of analysis” issues while conducting HCI studies. We also propose specific guidelines for addressing the gaps identified above.