With the growth of international healthcare operations, methods to improve connectivity are sought, along with a reduction in major barriers of electronic connectivity between global trading partners. To address these barriers, a conceptual agent-based framework following a proposed methodology for the analysis and design stages is developed to allow for improved ease of connectivity and interpretability between international trading partners. This framework is comprised of agents and is applied to connectivity between healthcare entities such as payers and providers. While many healthcare entities exchange information electronically, few do so without some form of manual intervention. Information systems may be engaged to further enhance the healthcare industry. Given the increases in costs and international presence, it is vital to make use of electronic systems that improve overall quality and cost of healthcare.