Mobile communication technologies have penetrated consumer markets throughout the world. It is likely to make a deep influence on business activities, consumer behavior, and national and global markets. Thus the identification of factors that impact mobile commerce adoption will have significant value. This paper identified nine factors affecting mobile commerce adoption by consumers, based on recently published research. Multiple comparisons in China and United States were conducted to clarify the applicability of these factors in the two regions. A survey was conducted on 190 individual mobile commerce users in China and US. We found significant differences among the antecedents and their impact on consumers’ intentions to use mobile commerce. The study also draws a number of practical insights and provides vendors seeking to enter the Chinese and US marketplace with specific information about m-commerce users’ perceptions and intentions.