The topic of collaboration in cross-organizational and cross-border settings is an emerging subfield of information systems research. This paper presents a compressive literature review of 52 research papers, published from 2000 to 2007, in four leading journals. The focus of the analysis are topics of investigation, sources of data, and the underlying theories. The results indicate that most of the research still focuses on a limited number of technical issues related to inter-organizational systems adoption. The identified research gaps which represent promising research opportunities are discussed.