This research investigated the effects of work practice compatibility (WPC) on user acceptance and continued use of an online disability evaluation system. The objectives were to examine the work practice compatibility and its effects on actual system use, to assess the patterns of use among the users, and to explore the implications for future system developments. An online web-based survey was distributed to a population of medical professionals, and 97 responses were obtained. Results of bivariate analysis suggested that WPC is an important indicator of actual and continual use. Further analysis revealed associations that give clear indications of the influence of WPC, training, and software features on the relationships between direct and sustained use of the system.