The rapid growth of mobile technology has expedited ubiquitous information access via handheld devices. However, the fundamental natures of mobile information systems are different from those of desktop applications in terms of purpose of use, device features, communication networks, and working environments. This poses various challenges to mobile information systems on how to deliver and present multimedia content in an effective and adaptive manner. One of the major challenges is to deliver personalized information to the right person in a preferred format based on the changing environment. This paper proposes an innovative framework for developing mobile applications that deliver personalized, context-aware, and adaptive content to mobile users. The framework consists of four major components: information selection, content analysis, media transcoding, and customized presentation. It can be applied to a variety of mobile applications such as mobile web, news alert services, and mobile commerce.