E-learning and virtual classrooms have proven to be efficient ways to discuss, exchange information and build shared knowledge amongst distributed participants. The paper presents 3 years of experiences gathered and the lesson learned through of an e-learning project conducted at the Catharina hospital. Results show that in such a 24-hour organization, he main advantage, of e-learning is to offer health care professionals the possibilities to engage in learning activities at a convenient time from their working place or from home. It emphasizes particularly on the importance to implement appropriated multimedia technologies. In one hand these new technologies bring a social dimension to the e-learning environment,, and in the other hand are of help to the instructors facing many electronic questions and comments. A classification grid is used to guide the complex and essential steps required deciding upon the use and the development of an electronic course in the healthcare sector. Special attention was given to the implementation of new multimedia technologies based on the expected fit between the learning strategy and the technology. With the support of appropriated multimedia tools , e-learning have been found to improve the quality of education in a cost-effective way, especially for nurses (N=84). The paper concludes that more research pilots have to be conducted in order to narrow down the classification .