Case-based research offers a platform for theory building in that rich and deep insights can be extracted from analysis of the data (Yin, 1989). Case research addresses “how” and “why” questions. Its purpose is to generalize to theory rather than to a population (Yin, 1989). This essay details why we believe that case-based research should be the prevalent research methodology used to address the complexity and dynamics inherent in the MIS field. We discuss current case research and potential outlets for this type of research.