This study conducts a survey to investigate the information systems professional's job stress and its outcomes in Taiwan's companies. The analysis is based on an organizational stress model. The results of this study indicate that (1) statistically significant difference exists between most of the job stressor and some items of the outcomes, (2) some moderating variables, such as type A personality and SDLC stage, are statistically significant in affecting the job stressor and the outcomes, and (3) statistically significant positive correlation exists between job satisfaction and psychological effects of the job stress.