Cybersecurity threats and vulnerabilities are causing substantial financial losses for governments and organizations all over the world. Intentional and unintentional users’ misuse of information systems (IS) resources represents 50% to 75% of cybersecurity threats. Computer Crime and Security Survey revealed that nearly 60% of security breaches occurred from inside the organization by authorized users. Computer users are deemed as one of the weakest links in the IS security chain. In this study, we examined the effect of user computer self-efficacy (CSE), cybersecurity countermeasures awareness (CCA), and cybersecurity skills (CS) on users’ computer misuse intention (CMI) at a government agency. Our results show that the factor of users’ awareness of computer monitoring (UAC-M) and cybersecurity initiative skill (CIS) were significant contributors to CMI. UAC-M and CSE were significant contributors to cybersecurity computing skill (CCS). Users’ awareness of security policy (UAS-P) was a significant contributor to cybersecurity action skill (CAS). However, CSE had no direct influence on misuse behavior. We conclude the paper with discussion about the results along with suggestions for future research.