Industrial applications of semantic technologies - in particular ontologies - include the integration of heterogeneous information sources and the management of information resources and services. Currently, the adoption of these technologies in large-scaled applications within enterprises is slowed down by their failure to meet some basic requirements of commercial applications. One of those is the support of sophisticated security policies for protecting the knowledge contained in ontologies and their instances from unauthorized use. In this paper, we propose a model-driven approach to enable access control for lightweight ontologies based on a role-based security model and well-known standard technologies.