This paper used Bibexcel, Netdraw and other software to obtain the bibliographic data of the literature, sourcing from CSSCI journals of China national knowledge infrastructure, in order to isolate the major academic groups of cross-border e-commerce and explore the evolution of keywords over the years. Also, the paper drew knowledge mapping according to the word frequency statistics and used keyword co-occurrence methods to investigate research topics and hotspots and clarified possible research trends. Results indicated that the number of cross-border e-commerce research achievements had grown rapidly, and the research themes primarily could be divided into six orientations. The study on cross-border e-commerce along the ‘Belt and Road’ countries has been increasing year by year. Furthermore, the research process should strengthen interdisciplinary cooperation and the level of theoretical innovation should be improved.