With the rapid usage rate of mobile phone and advances in healthcare technology, as well as current concerns arise over public’s health, mobile health are attracting the attention of more and more people. Although previous studies on the adoption of mobile services are quite extensive, few focus on public users’ adoption of mobile health service (MHS). In this study, we examine the determinants of user adoption of MHS based on Technology acceptance model (TAM). The findings confirm that perceived usefulness positively affect users’ attitude toward MHS, perceived service availability significantly impact on perceived ease of use and perceived usefulness, perceived usefulness and attitude directly enhance intention.