This paper studies radical innovation and its internal managerial control modes from the perspective of entrepreneurial orientation; then proposes a conceptual model and theory hypotheses. On analyzing the effective sample data from 682 enterprises of different industries across 10 provinces and cities in China, we have confirmed the theoretical model. The results indicate that entrepreneurial orientation more emphasizes radical innovation and manages it by strategic control; strategic control is more helpful for enterprise's radical innovation, financial control is not helpful for enterprise's radical innovation.